Quantitative proteomics of articular cartilage using sequential extraction of transverse cryosections
نویسندگان
چکیده
منابع مشابه
Quantitative proteomics at different depths in human articular cartilage reveals unique patterns of protein distribution.
The articular cartilage of synovial joints ensures friction-free mobility and attenuates mechanical impact on the joint during movement. These functions are mediated by the complex network of extracellular molecules characteristic for articular cartilage. Zonal differences in the extracellular matrix (ECM) are well recognized. However, knowledge about the precise molecular composition in the di...
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data envelopment analysis (dea) is a powerful tool for measuring relative efficiency of organizational units referred to as decision making units (dmus). in most cases dmus have network structures with internal linking activities. traditional dea models, however, consider dmus as black boxes with no regard to their linking activities and therefore do not provide decision makers with the reasons...
Quantitative structural organization of normal adult human articular cartilage.
OBJECTIVE Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and in attempting to establish this tissue's counterpart by engineering in vitro. A comprehensive set of such baseline data is, however, not available for humans. It was the purpose of the present study to furnish ...
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Introduction: T2 relaxation time mapping of free water content and mobility in articular cartilage provides an indirect assessment of collagen content and orientation [1]. Biochemical changes are characteristic of the early stages of osteoarthritis (OA), and T2 mapping is increasingly used in both clinical and research settings. New MR pulse sequences, including 3D approaches, provide more adva...
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The articular cartilage in the human knee joint functions in a highly demanding mechanical environment and its degeneration or defects have been, recently, treated with localized metal implants. The cartilage was found to grow onto the implant in the animal experiments. To simulate the cartilage growth, we have developed an axisymmetric human knee model with metal implant filling the assumed de...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2015
ISSN: 1063-4584
DOI: 10.1016/j.joca.2015.02.871